| Game 1 | |
San Francisco 49ers (2009) | 19
| | Arizona Cardinals (2009) | 23
| | Game 2 | |
Seattle Seahawks (2009) | 19
| | San Francisco 49ers (2009) | 18
| | Game 3 | |
San Francisco 49ers (2009) | 14
| | Minnesota Vikings (2009) | 28
| | Game 4 | |
St. Louis Rams (2009) | 3
| | San Francisco 49ers (2009) | 29
| | Game 5 | |
Atlanta Falcons (2009) | 9
| | San Francisco 49ers (2009) | 12
| | Game 6 | |
San Francisco 49ers (2009) | 15
| | Houston Texans (2009) | 27
| | Game 7 | |
San Francisco 49ers (2009) | 12
| | Indianapolis Colts (2009) | 25
| | Game 8 | |
Tennessee Titans (2009) | 16
| | San Francisco 49ers (2009) | 24
| | Game 9 | |
Chicago Bears (2009) | 25
| | San Francisco 49ers (2009) | 28
| | Game 10 | |
San Francisco 49ers (2009) | 31
| | Green Bay Packers (2009) | 33
| | Game 11 | |
Jacksonville Jaguars (2009) | 9
| | San Francisco 49ers (2009) | 15
| | Game 12 | |
San Francisco 49ers (2009) | 27
| | Seattle Seahawks (2009) | 12
| | Game 13 | |
Arizona Cardinals (2009) | 9
| | San Francisco 49ers (2009) | 7
| | Game 14 | |
San Francisco 49ers (2009) | 27
| | Philadelphia Eagles (2009) | 30
| | Game 15 | |
Detroit Lions (2009) | 22
| | San Francisco 49ers (2009) | 23
| | Game 16 | |
San Francisco 49ers (2009) | 29
| | St. Louis Rams (2009) | 3
|
San Francisco 49ers (2009)
Record 8-8
|
