| Location | | Predicted Line |
| |
| at | Tennessee Titans
| | Indianapolis Colts
| 26
| | Tennessee Titans
| 22
| -4
|
| |
| Neutral | | | Indianapolis Colts
| 28
| | Tennessee Titans
| 20
| -8
|
| |
| at | Indianapolis Colts
| | Indianapolis Colts
| 29
| | Tennessee Titans
| 19
| -10
|
| | Indianapolis Colts
| | Tennessee Titans
| |
| |
| | Stats | | Stats | |
| |
| | Comp | Att | Yds | Td | Int | QB Rating | | | Comp | Att | Yds | Td | Int | QB Rating |
| QB | Peyton Manning
| 26
| 38
| 281
| 2.71
| 1.14
| 101.11
| QB | Vince Young
| 19
| 31
| 197
| 1.7
| 1.11
| 83.01
|
| |
| | Yds | Td | | Yds | Td | |
| RB | Joseph Addai
| 64
| 0.66
| | RB | Chris Johnson
| 113
| 1.03
| |
| RB | Donald Brown
| 23
| 0.2
| | RB | LenDale White
| 25
| 0.13
| |
| RB | Mike Hart
| 10
| 0.13
| | RB | Vince Young
| 12
| 0.13
| |
| |
| | Yds | Td | | Yds | Td | |
| WR | Reggie Wayne
| 86
| 0.8
| | WR | Kenny Britt
| 50
| 0.0
| |
| WR | Dallas Clark
| 76
| 0.8
| | WR | Justin Gage
| 44
| 0.24
| |
| WR | Pierre Garcon
| 55
| 0.32
| | WR | Chris Johnson
| 39
| 0.24
| |
| WR | Austin Collie
| 50
| 0.56
| | WR | Nate Washington
| 35
| 1.22
| |
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